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KMID : 0359319930330030493
Korean Journal of Veterinary Research
1993 Volume.33 No. 3 p.493 ~ p.505
Clinico - pathological studies on the experimental lead poisoning in goats


Abstract
Present experiments were undertaken in order to clarify the clinico-pathological characteristics of lead poisoning in goats. Twenty goats were divided into three experimental groups(A, B and C) and a control (D). The three experimental groups received diets contaminated artificially with 10 (A group), 200 (B group) and 1,000 (C group) ㎍/g of lead for 70 days, respectively. The control group received normal diets. Hair samples collected one or two weeks interval were examed for the lead content. On day 70. all the animals were necropsied and various organs were examined pathoanatomically. In addition, various organs were analyzed for lead, zine, copper, iron and calcium content by atomic absorption spectrophotometry. From these experiments following results were obtained :
The lead content of hair was significantly increased from the 42^(nd), 21^(st) or 14^(th) day in all the three groups, which showed significant correlation with lead content of liver and spleen.
The lead content of various organs including kidney, liver, spleen, ileum, bone and abomasum were significantly increased in accordance with the lead contamination. The increase was most prominent in abomasal wall.
The zinc and copper content of liver, brain, ileum, skin, kidney, lung or muscle were increased in B and C groups whereas the iron and calcium content showed no significant change.
Pathoanatomically, degeneration or necrosis of proximal convoluted tubules of kidney, peripheral necrosis of liver, fundic gland necrosis of abomasum and cerebral edema were observed in B and C groups.
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학술진흥재단(KCI)