For understanding the role of infectious bursal disease virus(IBDV) to the pathogenesis of necrotic enteritis due to Clostridium perfringens(CP), all 15 day-old chickens used were divided as the following groups; A and E group with the feeding of feed contaminated with CP, B group with oral adminstration of IBDV(50㎕/head, 10^(3.4)EID_(50) of P₄strain) and simultaneously feeding of feed contaminated with CP, C group treated with IBDV alone, F group with the feeding of feed contaminated with CP at 3 weeks after oral inoculation of IBDV, D and G group with the feeding of normal feed as controls.
In mortality, B group(30%) was not a difference compared to A group(20%)(p$gt;0.05), but in the pathological lesions the former was more severe degree than the latter. The mortality of F group(70%) was a significant difference to those of A, B or E group (20%o)(p$lt;0.01). Also, showed much F group more marked lesions than A, B or E group. In the chickens occurred the death during the study, mean concentration of CP was reached at l0^8∼l0^9CFU/g in the intestinal contents. B group showed higher mortality and more severe pathological changes than A and E group.
Consequently, the results in the study were confirmed that the IBDV could be a role as a enhancing factor in pathogenesis of necrotic enteritis due to CP under the field condition.
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