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KMID : 0359319970370010203
Korean Journal of Veterinary Research
1997 Volume.37 No. 1 p.203 ~ p.212
Antibacterial efficacy and safety of copper sulfate pentahydrate to cultured fish

Abstract
Antibacterial efficacy and safety of copper sulfate pentahydrate (5% solution) was evaluated in laboratory and field studies for disinfection of some fish bacterial pathogens in cultured fish, flounder(Paralichthys olivaceus), mirror carp(Cyprinus carpio), gold fish(Carrassius auratus) and eel(Anguilla japonica). Dipping of fishes for acute toxicity was performed for a period of 48h, and the TLm value(median tolerance limit) were 4.0ppm in mirror carp and flounder, 4.4ppm in rainbow trout, and l0.0ppm in gold fish. After exposure below than TLm value for 1 month, no side effects and histopathological changes were observed.
The test drug were shown high antibacterial activities against most bacterial pathogens by exposure in the laboratory and field trials. However, Aeromonas salmonicida showed a resistance to the dosage. We can prevent outbreaks of bacterial diseases of fish by the dosage of 1ppm for 6hr and the test drug is thought to be used effectively and widely as a disinfectant against most bacterial fish pathogens.
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학술진흥재단(KCI)