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KMID : 0359319980380040837
Korean Journal of Veterinary Research
1998 Volume.38 No. 4 p.837 ~ p.842
Development of preventive method for enterotoxigenic colibacillosis using egg yolk antibodies
김종만/Kim, Jong Man
허원/권창희/김종염/우승룡/Huh, Won/Kweon, Chang Hee/Kim, Jong Yeom/Woo, Seng Ryong
Abstract
The present study describes the effectiveness of egg yolk antibodies (IgY) against enteric colibacillosis and edema disease in piglets. The antibodies were gained from the egg yolk of hens immunized with k88, k99, 987p fimbrial adhesin and heat-labile toxin antigens of enterotoxigenic Escherichia coli (ETEC). Orally-administered egg yolk antibodies solution protected against experimental challenge with ETEC K88^+ and k99^+ strains in neonatal piglets and mice. In field trial, a total of 598 diarrheal piglets were orally treated with 3㎖ of antibody once a day to determine for the therapeutic effect. Of them, 582 (97.3%) piglets were recovered from diarrhea in 3 days. We also experimentally treated with the egg yolk antibodies twice a day for 5 consecutive days for 94 weaning piglets with edema disease for the determination of therapeutic effects. Seventy four piglets (78.7%) were recovered from clinical edema signs. Theses findings indicate that egg yolk antibodies against k88, k99, 987p and LT of ETEC are
useful source of passive immunity for enteric colibacillosis and edema disease of piglets.
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학술진흥재단(KCI)