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KMID : 0359320140540040203
Korean Journal of Veterinary Research
2014 Volume.54 No. 4 p.203 ~ p.208
Stimulatory effects of Bordetella bronchiseptica antigen on bone marrow cells
Yim Seol-Hwa

Joo Hong-Gu
Abstract
Bone marrow is a hematological and immunological organ that provides multiple immune cells, including B lymphocytes, and thus plays a critical role in the efficacy of vaccine. We previously demonstrated that Bordetella (B.) bronchiseptica antigen has high immunogenicity in spleen cells, a peripheral immune organ. In this study, we investigated the immunogenicity of B. bronchiseptica antigen in bone marrow cells, a central immune organ. B. bronchiseptica antigen increased the cellular activity of bone marrow cells and significantly enhanced the production of nitric oxide, IL-6, and TNF-α. Bone marrow cells primed with B. bronchiseptica antigen in vivo were harvested and stimulated with the same antigen in vitro. The stimulation of B. bronchiseptica antigen significantly increased the cellular activity and proliferation rate of the primed cells. B. bronchiseptica antigen also greatly induced the production of antigenspecific antibody in the primed cells. Taken together, the present study demonstrated that B. bronchiseptica antigen can stimulate bone marrow cells, a central immune organ, and recall the immune response of the primed bone marrow cells.
KEYWORD
antigen, Bordetella bronchiseptica, immune memory responses, stimulatory effects, vaccine
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학술진흥재단(KCI)