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KMID : 0359320170570010047
Korean Journal of Veterinary Research
2017 Volume.57 No. 1 p.47 ~ p.50
Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs
Mongillo Paolo

Bernardini Marco
Prana Elisa
Balducci Federica
Gabai Gianfranco
Marinelli Lieta
Abstract
Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.
KEYWORD
cerebrospinal fluid, dehydroepiandrosterone, dogs, hydrocortisone, sex
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