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KMID : 0359320230630030009
Korean Journal of Veterinary Research
2023 Volume.63 No. 3 p.9 ~ p.9
Immune-mediated hemolysis after administration of human intravenous immunoglobulin in a dog: a case report
Kim Min-Ji

Kim Young-Ju
Bae Hyeon-A
Jung Ran-Kyung
Kang Min-Jeong
Cha Su-Min
Cho Kyu-Woan
Jung Dong-In
Yu Do-Hyeon
Abstract
A 10-year-old spayed female Maltese presented with purpura and hematemesis. Initial laboratory evaluation revealed immune-mediated thrombocytopenia, but evidence of hemolytic anemia was not identified. Three milligrams of human intravenous immunoglobulin (hIVIG) was administered for 3 hours following prednisolone and mycophenolate mofetil. A pale mucous membrane was identified, and the packed cell volume decreased by 3%. Blood film examination revealed significant spherocytosis with auto-agglutination. Blood transfusions and immunosuppression were continued for 4 days, and hIVIG was discontinued. This report describes a case of increased immune-mediated hemolysis after hIVIG administration, possibly due to new-onset immune-mediated hemolytic anemia or enhanced immunogenicity.
KEYWORD
human intravenous immunoglobulin, immune thrombocytopenic purpura, autoagglutination, autoimmune hemolytic anemia
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