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KMID : 03644199719970000059
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East-West Medical Research Institute Journal
1997 Volume.1997 No. 0 p.59 ~ p.65
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Effect of Ekongsan on the in vitro nephrotoxicity induced by cisplatin
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Abstract
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In vitro model systems are increasingly used to investigate the mechanism of chemicai-induced toxicity and for toxicological screening of new drug families. The effect of Ekongsan on the cytotoxicity induced by cisplatin on human and rabbit kidney cells was evaluated by tetra2,olium-dye(MTT) assay.
On the basis of CI5o value, cisplatin-induced cytotoxicity on human renal cortical cells was increased depend on concentration, whereas Ekongsan alone did not influence. Simultaneous administration of cisplatin and Ekongsan, cytotoxicity of cisplain was reduced depend on the concentration of Ekongsan. With primary cultured proximal tubule cells, results to reduce the cisplatin induced-cytotoxicity by Ekongsan was comparable to those with renal cortical cells. Based on these results, Ekongsan may has the potency to protect the rlephrotoxicity induced by cisplatin.
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