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KMID : 03644199719970000159
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East-West Medical Research Institute Journal
1997 Volume.1997 No. 0 p.159 ~ p.185
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Study on the Stability of Herbal Medicine for Iontophoresis
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Abstract
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Iontophoresis is a simple, well-documented method of drug application for medication of tissues. It is possible to medicate electrically any surface tissue with drugs having a positive or negative charge. The technique involves transporting selected ions electrically into a tissue by passing a direct electrical current through a medication solution and the patient, using selected electrode polarity. I am interested in applying herbal medicine to a new method of treatment in musculoskeletal inflammatory conditions instead of western medicine. It is necessary to study on the stability of herbal medicine before application of iontophoresis clinically. Corydalis Tuber, Carthami Flos, and Cnidii Rhizoma were selected and studied. The results are as follows.
1. There were no significant changes in the UV spectrum pattern of these herbal medicines.
2. In the electrical conductivity measurement, the conductivity of Corydalis Tuber ranged from 18.00 to .18.57 , that of Carthami Flos ranged from 17.58 to 18.28, and that of Cnidii Rhizoma ranged from 18.15 to 18.94 .
"There were no significant changes in the electrical conductivity in connection with the UV spectrum measurement.
3. In the pH measurement, the pH of all the herbal medicines was- measured between 7.06 and 7.07 in the begining, and ranged from 6.909 to 7.601. There were no significant changes in the pH in connection with the UV spectrum measurement.
4. In the quantitative analysis of ions, there were much more anions than cations in Corydalis Tuber.
5. In Carthami Flos and Cnidii Rhizoma, more anions were distributed than cations.
6. More anions distributed mainly within all the herbal medicines were Cl-,SO42- and metals were K, Na .
7. In the HPLC chromatogram, comparing herbal medicines in cold storage with herbal medicines at room temperature, there were no significant changes.
Based on these results, it shows that experemental herbal medicines have stability in the study.
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