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KMID : 03644199719970000233
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East-West Medical Research Institute Journal
1997 Volume.1997 No. 0 p.233 ~ p.251
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Studies on the effects of PUERARIAE RADIX(葛根) and ARTEMISIAE HERBA(茵蔯) on experimental liver damages induced by alcohol, d-galactosamine and CCI₄
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Abstract
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Recent survey shows that chronic liver disease such as chronic hepatitis, liver cirrhosis and hepatoma is the third leading causes for death in Korea. In oriental medicine, viral hepatitis is related to H%wigdal(Q-tj) and alcoholic liver disease is related to Joosang(OUD. ARTEMISIAE HERBA and PLERARTAE RADIX have long been used in treating those symptoms. This study was done to evaluate lot effect of ARTEMISIAE HERBA and PUERARIAE RADIX on viral and alcoholic hepatitis.
ARTEMISIAE HERBA and PUERARIAE RADIX were decocted respectively with water and followed_ by vaccum evaporation. The solution was diluted to adequate concentration.
Sprague-Dawley rats were used in this experiment. Each group was given PUERARIAE RAD or ARTENIISIAE HERBA solution orally and CC14, d-galactosamine or alcohol was givers orall 30 minutes later. After 24 hours of starvation, blood samples were taken to check serum Go GPT, LDH and ALP acitvities, TC, TG, glucose and BUN levels.
These results show that ARTENUSIAE HERBA has better effect on liver injury induced by d-Galactosamine than PUERARIAE RADIX and that both ARTENIISIAE HERBA and PUERARLAX RADIX have good effect on acute alcoholic liver disease while in the liver injury induced by CC) PUERARIAE RADIX has better inhibitory effect on serum AST, ALT and ALP levels aril ARTENIISIAE HERBA has better inhibitory effect on serum total cholesterol and triglyceride.
And the result that high concentration group has better effect shows these effects are conceltration-dependent. Further study on the mechanism of these herbs is still required.
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KEYWORD
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