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KMID : 0366519960160010145
Annual Bulletin Seoul Health
1996 Volume.16 No. 1 p.145 ~ p.153
Histopathologic Effects of Mitomycin C on the Sclera
Lee Koon-Ja

Abstract
Mitomycin C(MMC), widely used as an adjunct in the surgical treatment of pterygium, was instilled to the young rats to evaluate the histologic and histopathologic toxicity of the sclera. 1. Significant histologic changes were not detected in the lower dose of MMC(0.04mg/mL) treated groups, but lamella structure of sclera was irregular in the higher dose of MMC(0.1mg/ mL) treated groups. These structural changes were not recovered within 7days after ceasation of MMC instillation. 2. Alkaline phosphatase activity was decreased in the higher dose of MMC treated groups, and it was not recovered within 7 days after ceasation of MMC instillation. 3. Type I collagen and type I collagen synthetic activity of fibroblast were decreased in the lower and higher dose of MMC treated groups, and these changes were not recovered within 7 days after ceasation of MMC instillation. 4. Cu, Zn-SOD activity was increased in the lower dose of MMC treated groups and single application of higher dose of MMC, but Cu, Zn-SOD activity was not detected in the other higher dose of MMC treated groups. These results indicate that increase of Cu, Zn-SOD activity may reduce the MMC toxicity temporarily, but repeated MMC treatment changes the sclera irregular by decreasing biosynthesis of collagen in the fibroblast. These irregular lamella structure may lead to necrotizing scleritis.
KEYWORD
collagen, mitomycin C, MMC, necrotizing scleritis, pterygium, sclera
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