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KMID : 03772197919790000089
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Medical Journal of Chosun Univercity
1979 Volume.4 No. 1 p.89 ~ p.96
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Studies of the renal diseases on the cellulose acetate electrophoretic fractions of serum proteins
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宋基昌/Song, Ki-Chang
朴在允/車德源/金昌世/Park, Jae-Youn/Cha, Duk-Won/Kim, Chang-Se
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Abstract
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Cellulose acetate electrophoretic studies of renal diseases were performed and the follo- wing results were obtained
1) The mean values for the electrophoretic fractions of serum protein in nephrotic syn- drome mere 1.18±0.48gm/100㎖(28.65±8.03%), 0.25±0.19 gn/100㎖ (5.05±3.17%)1.46±0.57 gn/100㎖(35.95±12.83%), 0.72±0.28 gn/100㎖(17.32±5.39%), and 0.56±0.21gm/100㎖(13.45±4.47%), respectively, for the albnmi, α_l-, α_2-, β-, and γ- globulin fractions. It was found that decrensed both albumin 2.11gm/100㎖(19a17%), and γ-glo-bulin, 0.94gm/100㎖(7.83%), fractions were more marked than in control groups. While α_2-globulin fraction was markedly increased, 0.7gm/100㎖(25.37%), to compare in control group.
2) The correlation coefficient between albumin and α_2-globulin fractions in nephrotic syndrome was γ=-0.84 and regression equation, was y=-1.34x-74.40. 3) The A/G ratio was markedly reversed as 0.40±0.16.
4) The mean values for the electrophoretic fractions of serum proteins in nonnephrotic syndrome, i. e. , acute and chronic glomerulonephritis, renal failure, pyelonephritis, and renal stones, were 2.35±0.59gm/100㎖(40.74±8.54%), 0.27±0.13gn/100㎖(4.65±1.98%), 0.78±0.25gm/100㎖(13.30±2.84%), 0.93±0.28gm/100㎖(15.75±4.33%), and 1.43±0.58gm/100㎖(24.14±8.14%), respectively, for the albumin, α_l-, α_2-, β-, and γ- globulin fractions. It was found that decreased albumin and increased α_l-globulin fractions were marked than in control group.
5) In the biochemical data in nephrotic syndrome it was found that serum cholesterol was increased. 2.5 times than in control group. In non-nephrotic syndrome group it was found that increased concentration of serum K and markedly increased concentration of serum creatinine(4.5 times) and BUN(3 times) were shown.
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