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KMID : 03772198019800000031
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Medical Journal of Chosun Univercity
1980 Volume.5 No. 1 p.31 ~ p.38
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Effect of plasma-Free Fatty Acid Concentraion on Blood, Liver and Muscle Carnitine Contents in Rabbits
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池南喆/Chi, Nam Cheol
車鍾希/高光三/Cha, Jong Hee/Koh, Kwang Sam
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Abstract
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In normal conditions and starvation, the influence of the plasma-free fatty acid concentration on blood, liver and muscle carnitine contents with a intravenously and oral administered fat load was studied.
In normal rabbits, intralipid containing 10% soy bean oil emulsion increases the levels of plasma-flee fatty acid, plasma triglyceride, liver and muscle carnitine, but decreases the levels of blood and urinary carnitine, othe metabolite levels were charged ofter intralipid was administered. It was caused by the enhanced oxidation of increased free fatty acid.
In strarved rabbits, phsma-free fatty acid, acetoacetate and hydroxybutyrate levels were increased, while triglyceride, lactate and pyruvate levels were decresed. It resulted from the increases of f at decomposition, the fatty acid level and fatty acid oxidaion. Intralipid administratior, increases plasma-free fatty acid, triglyceride, liver and muscle carnitine acetoacetate and pyruvate levels but blood and urinary carnitine, and lactate and pyruvate levels were decreased. It resulted from the enhancement of fat synthesis from increased plasma-free fatty acid.
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