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KMID : 03772198019800000157
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Medical Journal of Chosun Univercity
1980 Volume.5 No. 1 p.157 ~ p.168
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Clinical Evaluation of Clonazepam (RO5-4023) on Uncontrolable Epilepsy, Especially on Psychomotor Seizures
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Abstract
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Clonazepam was administered via p. o. and i. v. routes to patients with uncontrolable epilepsy mainly consisting of psychomotor seizure.
The following results were obtained :
1) Clonazepam of 3∼5 mg/day was administered via p.o. route to 38 patients with other antiepileptic drugs. The effective rate was 73.6%. The average effective dose was 3.5mg/day. The drug was remarkably effective in patients with psychomotor seizure. Of 14 patients with psychomotor seizure, 7 patients (50%) responded exellently and 4 (29%) responded effectively. The drug was considered to be worth employing in this kind of incurable epilepsy. Furthmore, as seen in other reports, this drug showed effectiveness in the other spasm types, particuraly infantile spasm and petitmal varient.
2) In general, administration of more than 3 months fairly lowerea the effective rate, but in the most of cases efficient anti-epileptic effects which encouraged continuous administration were seen when administered continuously more than 6 months.
3) Two patients with status epilepticus were administered 1-2mg of clonazepam via i. v. route. In both of them complete inhibition of spasm, clearance of consciousness, and normalization of EEG were seen Just after the injection These effects continued for about 20-25 minutes. In our experience these effects were more remarkable than those when administered diphenylhydantoin and diazepam.
4) when administered orally, many patients complained of drowseness as a side effect, but this could be reduced by changing the dosage of this drug or combination of the other anti-epileptic drugs. Of 40 cases drop out cases because of this side effect were 2 cases. Other side effects were not seen except one case of hypersalivation, and results of clinical laboratory examinations could not find any adverse reactions attributable to this drugs.
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KEYWORD
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