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KMID : 0614019910070010115
Journal of Pharmaceutical Sciences (C.N.U.)
1991 Volume.7 No. 1 p.115 ~ p.138
Intestinal Immunity and Genetic Factors Influencing Colonization of Microbes in the Gut
H.S. Lillehoj and K. S. Chung
Abstract
Recent technical advances in the molecular and cellular immunology have enhanced our understanding of the ontogeny, structure, and function of gut-associated lymphoid tissues (GALT). Isolation of single cells from the intestine and flow cytometric analysis of lymphoid populations now enable researchers to dissect various components of the GALT and study the role of subpopulations of intestinal lymphocytes in various aspects of disease processes. The molecular characterization of cytokines involved in inflammation and immunity have allowed us to devise immunotherapeutic protocols. Recent in vivo trials of recombinant cytokines demonstrate promising uses of the lymphokines in immunoprophylaxis and immunoprevention. The availability of molecular probes and genetically defined chicken lines make it possible to study the role of host genetic factors influencing immunity to intestinal diseases. Genes of the major histo-compatibility complex(MHC) and non-MHC genes have been shown to influence disease resistance and the host immune response to infectious agents. This paper will review: (1) our current understanding of the intestinal immune system, (2) immunogenetics of the mucosal immune system, and (3) development of recombinant vaccines against intestinal infection.
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