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KMID : 0614020050200010001
Journal of Pharmaceutical Sciences (C.N.U.)
2005 Volume.20 No. 1 p.1 ~ p.19
Preparation and Evaluation of Solid Lipid Nanoparticles (SLN)
Kim Seo-Ryung

Park Jeong-Sook
Hwang Sung-Joo
Abstract
Solid lipid nanoparticles (SLN) represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. This paper presents an overview about the present state of the art regarding production techniques for SLN, drug incorporation, loading capacity, drug release and different ways of SLN applications. Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industriai large scale production are also discussed. Special attention is paid to the relation between drug incorporation and the complexity of SLN dispersions and the physical state of the lipid (supercooled melts, different lipid modifications). Appropriate analytical methods are needed for the characterization of SLN. The use of several analytical techniques is a necessity. Alternative structures and dynamic phenomena on the molecular level have to be considered. Aspects of SLN administration and the in vivo fate of the carrier are discussed. The potential of SLN to be exploited for the different administration routes is highlighted. References of the most relevant literature published by various research groups around the world are provided.
KEYWORD
Solid lipid nanoparticles, Colloidal drug carrier, Controlled release, Drug incorporation, Coexistence of different colloidal species, Administration routes, SLN quality and structure, Production parameters
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