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KMID : 0614020050200010041
Journal of Pharmaceutical Sciences (C.N.U.)
2005 Volume.20 No. 1 p.41 ~ p.46
Anaysis of acanthoic acid and isomers in Acanthopanax species by gas chromatography
Kamg Ji-Youn

Jeong Young-Hee
Lim Eun-Hee
Lee Eun-Joo
Zhu Hong-Mei
Jeong Su-Jin
Bae Ki-Hwan
Kim Young-Ho
Kang Jong-Seong
Abstract
Acanthoic acid, continentalic acid and kaurenoic acid are bioactive diterpenoids which were structural isomers isolated from Acanthopanax species. For the quality evaluation of Acanthopanax species a gas chromatographic method for the separation and quantitation of these isomers was developed. Three compounds were successfully separated from the extracts of leaves, stems and roots of Acanthopanax species. GC-MS provided the identification of components separated from the extracts. Adequate separation of the components from Acanthopanax species was achieved on a fused-silica dimethyl polysiloxane capillary column (15 m x 0.25 ㎜, 0.25 ㎛ film thickness) operated with temperature programming from 160℃ held 0.5 min, increased at 11℃/min to 290℃ held 0.5 min with the carrier gas flow-rate (helium) of 5.1 ㎖/min. Among six Acanthopanax species only two species (A. koreanum and A. trifoliatus) contained the diterpenoids indication that the two species might possess the taxonomical similarity.
KEYWORD
Acanthopanax species, quality evaluation, diterpenoids, GC-MS
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