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KMID : 0615219950200010155
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Journal of Kwangju Health
1995 Volume.20 No. 1 p.155 ~ p.162
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Isotyping and Cross-reaction of mouse anti-HIV-1 p24 Monoclonal Antibodies
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이영종/Lee YJ
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Abstract
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In order to improve the relizbility immunodiagnostic techniques being used in the diagnostic of HIV-1, mouse anti-HIV-1 p24 monoclonal antibodies were isotyped and cross-reacted.
When monoclonal antibodies against HIV-1 p24 protein were isotyped, they were confirmed IgG_2b/? which H and L chain were y_2b and k chain, respectively.
To confirm the cross-reaction for another viral proteins, mouse anti-HIV-1 p24 IgG_2b/? was reacted with HBV proteins. However, the reaction did not occur. Thus, it was confirmed that mouse anti-HIV-1 p24 IgG_2b/? only bound to HIV-1 p24 protein.
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KEYWORD
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