|
KMID : 0857020050200010141
|
|
Kosin Medical Journal
2005 Volume.20 No. 1 p.141 ~ p.146
|
|
|
The expression and clinical implication of GAGE gene in Stomach Cancer
|
|
Kong Eun-Hee
Chang Hee-Kyung
|
|
|
Abstract
|
|
|
Background: There is still little information on the function of GAGE gene in the stomach cancer except for cancer-specific gene expression recognized by autologous T lymphocytes. This study attempted to evaluare GAGE mRNA expression to elucidate its functional role in the carcinohistogenesis and clinical implication in gastric cancer.
Material and Method: Tumor and non-neoplastic paired samples from 60 patients with gastric cancer were studied by using reverse transcription - nested polymerase chain reaction (RT-PCR) with common primer.
Result: No expression of GAGE was observed in non-neoplastic tissues. Fifteen out of 60 tumor tissues expressed GAGE (25.0%) mRNA, of which 13 cases (86.7%) were intestinal type and only 2 cases (13.3%) were diffuse type. GAGE expressions in cancer tissues have a significant tendency to be higher by stage and lymph node metatastasis (p＜0.05). However, they did not show significant relationship with tumor cell differentiation and vascular and perineural invasions.
Conclusions: This results suggest that GAGE gene might have an important role in the development and progession of intestinal type of stomach cancer and GAGE gene may be a useful molecule for target of cancer-specific immunotherapy.
|
|
|
KEYWORD
|
|
|
Stomach cancer, GAGE gene, histogenesis, immunotherapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|