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KMID : 0878619990030020108
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Korean Journal of Pediatric Anesthesia
1999 Volume.3 No. 2 p.108 ~ p.112
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The Effect of Pretreatment of Sedatives on the Fentanyl Cough Reflex in Pediatrics
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Cho Jeong-Ok
Son Yoon-Suk
Noh Si-Yeon
Son Soo-Chang
Shin Yong-Sup
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Abstract
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Background: Fentanyl has been used during anesthesia to stabilize hemodynamic response. But it can induce cough in some patients. We investigated the effect of pretreatment of propofol and ketamine on the fentanyl cough reflex (FCR) in pediatrics.
Methods: 151 patients (ASA class 1, 2) were assigned randomly to 3 groups: Group 1 (no pretreatment group, n=82), Group 2 (pretreatment of ketamine 5 ㎎/㎏ im, or 2 ㎎/㎏ iv, n=51), Group 3 (pretreatment of propofol 2 ㎎/㎏ iv,
n=18). Before induction of anesthesia, fentanyl was injected rapidly through peripheral venous cannula and rapid fluid infusion was followed in each group. We checked the incidence, onset time and maintenance time of FCR.
Results: There was significant difference in the incidence of FCR between Group 1 (48.8%), Group 2 (11.85%), and Group 3 (33.3%). Maintenance time was decreased significantly in pretreatment group (2.79 sec in Group 1, 0.22 sec in Group 2 and 1.33 sec in Group 3).
Conclusions: Fentanyl can induce couh reflex in some pediatrics and this reflex is decreased with propofol and ketamine pretreatment.
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KEYWORD
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Anesthetics, intravenous: fentanyl, ketamine, propofol, Complication: cough
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