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KMID : 0878620010050010034
Korean Journal of Pediatric Anesthesia
2001 Volume.5 No. 1 p.34 ~ p.38
Malignant Hyperthermia during General Anesthesia
Cho Hyoung-Chan

Kang Sung-Joon
Choi Wan-Soo
Shin Il-Woo
Lee Heon-Keun
Chung Young-Kyun
Abstract
Malignant hyperthermia is a dramatic syndrome that rarely arises during anesthesia and is defined as a potentially fetal hypermetabolic syndrome characterized by hyperpyrexia, skeletal muscle rigidity, tachycardia, cyanosis, respiratory and
metabolic acidosis etc. Any inhalation anesthetic agent or any skeletal muscle relaxant can trigger this acute catastropic reaction. A case is presented of a 12 years old male patient in whom congenital muscular torticollis correction was planned under oxygen-nitrous oxide-enflurane anesthesia with induction by thiopental sodium. One and a half hours after induction, tachycardia developed, followed by hyperpyrexia, and muscular rigidity. Under the suspicion of malignant hyperthermia, all inhaled anesthetics were discontinued. Vigorous emergency treatment was attempted. A cold intravenous solution were started and gastric lavage with cold saline and cooling the body surface with iced saline was initiated. The patient was treated successfully with early detection and intensive care. Seven hours after induction, dantrolene 120§· was intravenously injected. The postoperative course was uneventful and the patient was discharged without any sequelae.
KEYWORD
Anesthetics: enflurane, Hyperthermia: malignant, Pharmacology: dantrolene
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