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KMID : 0878620020060010015
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Korean Journal of Pediatric Anesthesia
2002 Volume.6 No. 1 p.15 ~ p.19
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The Effect of Ketorolac on Emergence Delirium after Sevoflurane Anesthesia in Children
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Chung Chong-Dal
Choi Kyu-Seob
Yu Byung-Sik
An Tae-Hun
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Abstract
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Background: Children usually exhibit pain-related behavior (agitation) in the postanesthetic care unit. The aim of the present study was to compare the emergence and recovery profiles of children who received sevoflurane with or without supplementary ketorolac.
Methods: Twenty eight children (classified as ASA physical status 1) scheduled for elective surgery were randomly assigned to eight ketorolac (n=15) or no ketorolac (n=13). All children were premedicated with midazolam (0.05 ㎎/㎏) and glycopyrrolate (0.004 ㎎/㎏) and hour before anesthesia induction. Thiopenthal sodium (5 ㎎/㎏) and vecuronium bromide (0.1 ㎎/㎏) were used for the induction of anesthesia. After induction, group 1 did not receive ketorolac while group 2 received ketorolac. Anesthesia was maintained by inhalation of sevoflurane 2 vol% in N2O/O2 50/50 via an endotracheal tube. Recovery was assessed by an independent observer using a postanestheic recovery score. Pain score was also assessed by an independent observer using Faces Scale. Recovery characteristics and agitation characteristics on emergence were also compared with each other between the two groups.
Results: There were no differences between groups in respect of age, weight, duration of inhalation exposure, recovery score, and agitation incidence. Agitation score and duration were less in ketorolac group but there were no statistical difference. Delirium incidence and pain score were less in ketorolac group(P<0.05).
Conclusions: Incidence of agitation after sevoflurane anesthesia was no significance statistically between the two groups but, incidence of emergence delirium after sevoflurane anesthesia was reduced in ketololac group. Thus, it is assumed that postoperative analgesic action of ketololac reduces emergence delirium during recovery from sevoflurane anesthesia.
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KEYWORD
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Agitation, children, emergence delirium, ketorolac, sevoflurane
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