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KMID : 0878620030070010037
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Korean Journal of Pediatric Anesthesia
2003 Volume.7 No. 1 p.37 ~ p.42
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The Effects of Intavenous Induction Doses of Ketanine and Thiopental Sodium on the MACincision of Sevoflurane in Children
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Han Jong-In
Chung A-Ri
Lee hee-Seung
Kim Dong-Yeon
Chung Rack-Kyung
Kim Chi-Hyo
Lee Guie-Yong
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Abstract
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Background: We have investigated the hemodynamic response to surgical incision under intravenous induction with ketamine or thiopental sodium followed by sevoflurane anesthesia for maintenance because intravenous administration of ketamine before incision can affect the minimum alveolar concentration of sevoflurane that block the responses to surgical incision.
Methods: Fifty children (classified as ASA physical status 1 or 2) scheduled for elective inguinal hernionhaphy were randomly assigned to either ketamine induction group (2 mg/kg, group K) and pentothal induction group (5 mg/kg, group P). After intravenous induction, all patients were under controlled ventilation with rocuronium 0.4 mg/kg and sevoflurane 5.0 vol%. After 2 minute ventilation, endotrachel intubation was performed and the concentration of sevoflurane was decreased to 2 vol% with N₂0:0₂ of 2 L : 2 L and maintained until skin incision performed. After skin incision, inspiratory fraction of sevoflurane was increased or decreased according to the change of heart rate. We recorded the end tidal concentration of sevoflurane, blood pressure, and heart rate before induction, after induction, intubation, and skin incision, 5 minute after skin incision, and 10 minute after skin incision.
Results: There were no differences between groups in respect of age, weight, time from intubation to skin incision and heart rate at every evaluated time. The blood pressure of group K were higher than those of group P at the time after induction and intubation. The end tidal concentrations of sevoflurane of 5 minute after skin incision (1.97±0.29%, 1.88±0.20%) and 10 minute after skin incision (1.81±0.34%, 1.72±0.30%) were not significantly different between groups.
Conclusions: Intravenous induction dose of ketamine didn’t have any effect to the MAC incision of sevoflurane compared with pentothal sodium because the change of heart rate were not different between two groups.
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KEYWORD
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ketamine, pentothal sodium, sevoflurane, MAC, heart rate
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