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KMID : 0878620030070020082
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Korean Journal of Pediatric Anesthesia
2003 Volume.7 No. 2 p.82 ~ p.85
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Effect of Intravascular Volume Therapy with a Hydroxyethyl Starch(HES 200/0.5) on Blood Coagulation in Children Undergoing Cardiac Surgery
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Kim Kyoung-Ok
Lim Kyoung-Ji
Kim Chong-Sung
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Abstract
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Background : Hydroxyethy; starach (HES) is used for intravascular volume expansion in cardiac surgery. Studies show conflicting effects of intraoperative HES administration on postoperative bleeding We evaluated the effects of intraoperative HES infusion shortly after termination of cardiopulmonary bypass (CPB) on hemostasis following a cardiac operation.
Methods : According to a prospective, random sequence, 20 patients undergoing cardiac surgery received either 10 ml/kg of fresh frozen plasma (n=10) or HES 200/0.5 (n=10) shortly after termination of CPB. From arterial blood samples, standard coagulation variables were measured.
Results : While the use of allogenic blood/blood products and aPTT did not differ significantly between the two groups, blood loss during 2 hours after end of surgery and PT increased significantly in HES group.
Conclusions : Our study suggests that intraoperative use of HES 200/0.5 in primary cardiac surgery with CPB may increase postoperative bleeding. A large prospective study is needed to determine if intraoperative administration of HES 200/0.5 should be avoided in children undergoing cardiac surgery.
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KEYWORD
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Hydroxyethyl starch, cardiopulmonary bypass
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