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KMID : 08793198619860000393
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Annuals of Clinical Study - Seoul National Hospital
1986 Volume.1986 No. 0 p.393 ~ p.406
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Neurophysiology of infantile autism
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Abstract
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Neurophysiologic hypotheses of infantile autism fall into two broad categories. One is a caudally directed sequence of pathophysiologic influence originating in telencephalic structure.
The other is a rostrally directed sequence of pathophysiologle influence originating in brainstem and diencephalic structures. This paper relates each hypothesis to relevant aspects of autistic behavior, reviews neurophysiologic research relevant to each hypothesis, and describes recently completed studies of vestibular nystagmus, relating these new findings to thebrains-tem-diencephalic hypothesis. Author also analyze the behavioral and motor disturbances in childhood autism.
On the basis of analogy to signs and conditions seen in adult neurology, author propose that the syndrome results from dysfunction in a system of bilateral neural structures that includes the ring of mesolimbic cortex located in the medial frontal and temporal lobes, the neostriatum, and´ the anterior and medial nuclear groups of the thalamus.
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KEYWORD
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