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KMID : 08793198719870000343
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Annuals of Clinical Study - Seoul National Hospital
1987 Volume.1987 No. 0 p.343 ~ p.354
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A Study on the Pharmacotherapy in Refractory Schizophrenia
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Kim Cheol-Kyu
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Abstract
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This study had been conducted to elucidate the adjunctive antipsychotic effects of alprazolam in refractory schizophrenia.
38 hospitolized schizophrenic patients who met DSM-III criteria and had been refractory to standard neuroleptic treatment were selected. The patients were subdivided into two groups; alprazolam combined group and placebo combined group.
The duration of study is 7 weeks of alprazolam increase, maintenance and tapering period after 2 weeks of washout period.
The results were as follows:
1. Apprazolam combined group showed no significant difference in total scores and four sub-groups´ scores of BPRS (Brief Psychiatric Rating Scale), compared with placebo combined group during 7 weeks.
2. We found no significant changes in total BPRS scores and four subgroups´ scores in the alprazolam combined group during the study.
3. There was significant different between two groups in the evaluation of ATRS (Abrams-Taylor Rating Scale for Emotional Blunting) done at the time point of 4th week but the scores of alprazolam combined group were higher than those of placebo combined group.
4. Scores of ATRS and withdrwal-retardation subgroup in BPRS were shown to be increased during 1st and 2nd stages and decreased during 3rd stages, supposed to be due to sedative effect of alprazolam.
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KEYWORD
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