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KMID : 08793199319930000409
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Annuals of Clinical Study - Seoul National Hospital
1993 Volume.1993 No. 0 p.409 ~ p.416
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감규상
이경덕
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Abstract
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Drug effect is depend on bioabailability of preparation and also bioabailability is largely depend on dissolution rate. As matter of the fact, This paper was attepted to evaluate bioabailability of preparations for drug choice among many preparation from the dissolution test and content uniformity test of commercial prednisolone tablets. The dissolution test was conducted in artificial gastric juice in artificial intestinal juice and in aquas using basket method with six prednisolone preparations (A, B. C, D, E and F) which were pharmaceutically equivalent. The results were as follows :
1) The dissolution rate was higher in the order of six different brands A>C>F>B>E>D
2) Content uniformity of six different brands was better in such order as F>A>B>E>D>C
3) There was no relationship between dissolution rate and content uniformity.
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KEYWORD
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