|
KMID : 08793200120010010071
|
|
Annuals of Clinical Study - Seoul National Hospital
2001 Volume.2001 No. 1 p.71 ~ p.77
|
|
|
Attention Deficit/Hyperactivity Disorder : Predicting Factors and Clinical Response to Methylphenidate
|
|
장안기/Chang AK
강경미/서경란/Kang KM/Seo KR
|
|
|
Abstract
|
|
|
Objective : To investigate the effects of different dosage of methylphenidate(MPH) on cognitive functioning and behaviors of children with attention deficit/hyperactivity disorder(AD/HD), and to find predicting factors of favorable clinical esponses of AD/HD to the treatment with MPH.
Method : The subjects were 52 Korean children with AD/HD aged 6 to 12 years. A single-blind experimental design was used to evaluate the effect of MPH, at five different doses(placebo 5, 10, 15 and 20mg), on children's cognitive functioning and behaviors at home and in school.
Results : Standard statistical analyses of the clinical effect indicated that large proportions of treated children exhibited significantly improved behavior and attention. AD/HD groups with or without response to MPH differed in the rates of comorbidity and level of family functioning. Familiar adversity and psychiatric comorbidity may be clinical useful predictors of which children with AD/HD will be failed to respond to drug therapy.
Conclusion : Larger proportion of treated children with MPH exhibited significantly improved and normalized behavioral measures at home & school and attention test. 15mg dose resulted in significant improvement for behavioral and attention measures compared with baseline, 5, 10 and 20mg. AD/HD groups with or without response to MPH differed in the attentional and home behavioral measures at the baseline. The level of hyperactivity and impulsivity, school behavioral measures, and family functioning were not differed between two groups. We suggest that a good response to MPH is predicted by more impaired performance on attention test.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|