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KMID : 0964020130130010057
Journal of the Korean Liver Cancer Study Group
2013 Volume.13 No. 1 p.57 ~ p.61
A Case of Huge Hepatocellular Carcinoma with Complete Remission of Intrahepatic Tumor and Adrenal Gland Metastasis Treated with Combination Therapy of Transarterial Chemoembolization and Radiation Therapy and Sorafenib
Hwang Sang-Youn

Lee Seon-Mi
Im Jung-Woo
Kim Joon-Suk
Ahn Sang-Bu
Ji Eun-Kyeong
Choi Chul-Won
Yang Kwang-Mo
Abstract
Extrahepatic metastasis (EHM) associated with hepatocellular carcinoma (HCC) has been increasing due to prolonged survival with recent advances in therapeutic approaches including locoregional therapy such as transarterial chemoemoblization (TACE), radiofrequency ablation and radiation therapy (RT). Though many guidelines recommended systemic therapy such as sorafenib in this situation, some clinicians or centers still select locoregional therapy because the survival improvement of 2 or 3 months by sorafenib is far from optimal. Moreover, some studies showed that complete and partial response of intrahepatic tumors can result in significant improvement of patient survival even in situation of EHM. Based on above suggestions, we herein offer our experience of a patient with complete remission of intrahepatic tumor and adrenal gland metastasis treated with combination therapy of TACE and RT and sorafenib. Further study, maybe regarding a combination of locoregional and systemic therapy (so called multidisciplinary approach), is necessary on how to manage HCC patients with EHM.
KEYWORD
Hepatocellular carcinoma, Extrahepatic metastasis, Trasnarterial chemoembolization, Radiation therapy
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