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KMID : 1036520140040010006
Clinical Neuro-Ophthalmology
2014 Volume.4 No. 1 p.6 ~ p.7
Topographical Disorientation: Its Clinical Implication
Moon So-Young

Abstract
Topographical disorientation (TD) refers to the individuals’ inability to orient in the environment. TD may occur following lesions in different parts of the brain including medial temporal regions such as the the hippocampus and parahippocampal cortex, the fusiform gyrus and more posterior temporo-occipital regions including the lingual gyrus, posterior cingulate gyrus or posterior parietal cortex. Lesions in these selective brain regions may result in specific cognitive impairments such as anterograde disorientation, landmarks agnosia, heading disorientation, or egocentric disorientation which severely affect the individuals’ ability to orient in familiar or unfamiliar surroundings. The occurrence of TD in mild cognitive impairment patients correlates with gray matter loss in the brain regions reported as being responsible for orientation in humans.
KEYWORD
Topographical disorientation, Mild cognitive impairment
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