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KMID : 1036520170070020041
Clinical Neuro-Ophthalmology
2017 Volume.7 No. 2 p.41 ~ p.45
Paraneoplastic Cerebellar Degeneration with Anti-Yo Antibody Manifested by Central Nystagmus and Abnormal Head Impulse Test
Kim Ji-Min

Cho Ki-Hyun
Park Myung-Ho
Lee Seung-Han
Abstract
Anti-Yo antibody is the most frequently detected autoantibody in paraneoplastic cerebellar degeneration which manifests progressive gait and limb ataxia, vertigo and nystagmus. Here we report the case of a 42-year-old woman who was diagnosed with paraneoplastic cerebellar degeneration with anti-Yo antibody associated with breast cancer. The patient showed abnormal head-impulse tests with perverted catch-up saccades compatible with the cerebellar dysfunction along with spontaneous downbeat, gaze-evoked and rebound nystagmus. Even after active treatments such as surgical tumor resection, chemotherapy, radiotherapy, and immunotherapy, the symptoms persist for more than one year.
KEYWORD
Paraneoplastic cerebellar degeneration, Ataxia, Gaze-evoked nystagmus, Head impulse test, Anti-Yo antibodies
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