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KMID : 1039320160160020134
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Journal of Liver Cancer
2016 Volume.16 No. 2 p.134 ~ p.138
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A Case of Advanced Hepatocellular Carcinoma with Portal Vein Tumor Invasion that Showed Favorable Prognosis after Combined External Radiation Therapy and Sorafenib Therapy
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Paik Nam-Young
Sinn Dong-Hyun
Park Hee-Chul
Jeong Woo-Kyoung
Kim Min-Sun
Kim Ji-Hye
Yang Bum-Hee
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Abstract
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A prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is dismal that the median survival is 2 to 4 months without treatment. Sorafenib, the standard regimen of advanced HCC, can prolong median survival only 1.5 months. A 50-year-old man with a history of chronic hepatitis B was diagnosed advanced HCC with PVTT. By a multidisciplinary medical team approach, the combination of 3-demensional conformal radiation therapy with sequential sorafenib was challenged. 4 months after initiation of treatment, he achieved partial response as modified response evaluation criteria in solid tumors criteria. Sorafenib was continued so far, and stable disease has been maintained up to now, without significant adverse effect.
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KEYWORD
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Hepatocellular carcinoma, Sorafenib, Radiation therapy
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