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KMID : 1039320180180010001
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Journal of Liver Cancer
2018 Volume.18 No. 1 p.1 ~ p.8
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Translational Application of Single-cell Transcriptomic Analysis in Hepatocellular Carcinoma
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Yoon Seung-Kew
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Abstract
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The emergence of single-cell technology in recent years has made remarkable progress for understanding of biological process in various diseases including cancers. In particular of cancer, single-cell transcriptome analysis provides a powerful tool for comprehensive characterization of cancer cell subpopulations within a heterogeneous bulk populations. Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer and its molecular mechanism is extremely complex associated with a poor prognosis. To date, the molecular mechanisms of hepatocarcinogenesis remain unclear. Here, I review current status of single-cell transcriptome analysis for HCC, focusing on their application for cancer genomics, circulating tumor cells, cancer stem cells and tumor infiltrating cells in HCC.
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KEYWORD
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Sequencing, Hepatocellular carcinoma, Transcriptome, RNA sequencing, Circulating tumor cells
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