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KMID : 1039320200200010017
Journal of Liver Cancer
2020 Volume.20 No. 1 p.17 ~ p.24
Histopathological Variants of Hepatocellular Carcinomas: an Update According to the 5th Edition of the WHO Classification of Digestive System Tumors
Kim Hae-Ryoung

Jang Mi
Park Young-Nyun
Abstract
Hepatocellular carcinoma (HCC) is heterogeneous in pathogenesis, phenotype and biological behavior. Various histopathological features of HCC had been sporadically described, and with the identification of common molecular alterations of HCC and its genomic landscape over the last decade, morpho-molecular correlation of HCC has become possible. As a result, up to 35% of HCCs can now be classified into histopathological variants, many of which have unique molecular characteristics. This review will provide an introduction to the variously described histopathological variants of HCC in the updated WHO Classification of Digestive System Tumors.
KEYWORD
Classification, Hepatocellular carcinoma, Pathology
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