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KMID : 1039320200200010067
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Journal of Liver Cancer
2020 Volume.20 No. 1 p.67 ~ p.71
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Recurrent Coronary Artery Vasospasm in a Patient with Hepatocellular Carcinoma Treated with Sorafenib: a Case Report and Literature Review
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Lim Dae-Hyun
Yoo Jai-Hoon
Jun Dae-Won
Lee Oh-Young
Yoon Byung-Chul
Lee Hang-Rak
Kim Kyung-Soo
Choi Ho-Soon
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Abstract
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Tyrosine kinase inhibitors are widely used as targeted treatments for various malignancies. Sorafenib is an orally active tyrosine kinase inhibitor that blocks the signaling pathways of several growth factors. Its use is approved for various malignancies such as unresectable hepatocellular carcinoma, renal cell carcinoma, and gastrointestinal stromal tumors. Several adverse effects have been reported in the literature; however, cardiotoxicity is rare. We present a case of recurrent coronary vasospasm caused by short-term administration (5 days) of sorafenib. Since it caused refractory ischemia after re-administration, we had no choice but to stop the treatment.
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KEYWORD
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Sorafenib, Coronary artery vasospasm, Variant angina, Tyrosine kinase inhibitor, Vascular endothelial growth factor inhibitor
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