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KMID : 1039320200200020177
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Journal of Liver Cancer
2020 Volume.20 No. 2 p.177 ~ p.182
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Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
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Jo Hyun-Ho
Chun Seong-Joon
Yoo Jeong-Ju
Lee Min-Hee
Kim Sang-Gyune
Kim Young-Seok
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Abstract
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JX-594 is a modified oncolytic poxvirus designed to selectively replicate in and destroy cancer cells. In a pilot study, JX-594 injection followed by sorafenib was well-tolerated in three patients and associated with objective tumor responses. In this study, we report a case in which a patient with advanced hepatocellular carcinoma and portal vein thrombosis was treated with a combination of JX-594 and sorafenib.
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KEYWORD
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Oncolytic virus, JX-594, Sorafenib
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