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KMID : 1039620110010010001
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Korean Journal of Family Practice
2011 Volume.1 No. 1 p.1 ~ p.6
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Leaky Gut Syndrome
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Jeon Woo-Kyu
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Abstract
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The official definition of leaky gut syndrome from Wikipedia is "an increase in permeability of the intestinal mucosa to luminal macromolecules, antigens and toxins associated with inflammatory degenerative and/or atrophic mucosal damage." The intestine is an organ involved with the absorbing processing and transporting of food into the body. However, if one were to assess the immunological portion of the intestine and compare it with better-known mmunologically functioning organs such as the spleen, the intestine would be found to the largest such organ and the extent of its immunologic function would be found to be equally proportionate. Mucosal surface of the intestine has the ability to respond to and effector cells capable of protecting the host from potentially harmful organism or local antigens. When increased intestinal permeability (leaky gut syndrome), pathogenic bacteria and its products, toxins, antigens, hemiclas and incompletly digested food penetrate the intestinal epithelium and trnasported throughout the body. They ctivate the immuune system and effect the pathophysiology of acute and chronic inflammatory disease and autoimmune disease. Therefore, we should understand the importance of gut barrier function and the pathophysiology of leaky gut related immunologic disease, can make the helpful suggestions for achieving optimal human health.
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KEYWORD
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Leaky Gut, Permeability, Intestine
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