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KMID : 1039620110010010040
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Korean Journal of Family Practice
2011 Volume.1 No. 1 p.40 ~ p.47
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The Comparison of Arterial Stiffness between Normotensive and Prehypertensive Adults
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Kim Hyeon-Jeong
Lee Sang-Wha
Lee Hong-Soo
Shim Kyung-Won
Chun Hye-Jin
Kim Soo-Yeon
Kim Joo-Yeon
Oh Hye-Young
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Abstract
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Background: Prehypertension frequently evolves to hypertension and increases cardiovascular risk. The cardiovascular risk is increased according to the level of arterial stiffness. Although it has been shown that there is a relationship between
hypertension and arterial stiffness, there is not sufficient data about arterial stiffness in patients with prehypertension.
The present study was designed to evaluate arterial stiffness in prehypertensive adults.
Methods: We evaluated arterial stiffness of 619 prehypertensive adults and of 635 normotensive adults. Atic pulse wave
velocity (aPWV) was measured as indices of elastic-type aortic stiffness.
Results: A total of 1,254 subjects were examined on all components. The mean age in normotensive adults was 43.93 ± 6.22 years and in prehypertensive adults was 43.74 ± 6.48 years. aPWV (9.41 ± 0.94 vs. 9.91 ± 0.92 m/s, P < 0.001) and heart rate (61.55 ± 7.95 vs. 65.53 ± 8.71 bpm, P < 0.001) were significantly higher in prehypertensive adults than in normotensive adults. The aPWV was increased according to the level of blood pressure. The aPWV was observed to be positively correlated with age, height, weight, waist, systolic blood pressure, diastolic blood pressure, triglyceride, total cholesterol, lowdensity lipoprotein cholesterol, creatinine. High-density lipoprotein cholesterol was negatively correlated with aPWV. In multiple linear regression analysis, we found that the diastolic blood pressure was a significant predictor of aPWV (B =0.020, P = 0.04).
Conclusion: Our findings indicate that aPWV was significantly higher in adults with prehypertension than in the control group. The diastolic blood pressure was associated with aPWV after adjustment for the risk factors of cardiovascular diseases.
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KEYWORD
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Prehypertension, Aortic Pulse Wave Velocity, Diastolic Blood Pressure
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