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KMID : 1039620110010020094
Korean Journal of Family Practice
2011 Volume.1 No. 2 p.94 ~ p.100
Association between Serum Cystatin C Level and Visceral Fat in Healthy Individuals with Normal Kidney Function
Hong Jeong-Ah

Lee Kwang-Mee
Son You-Na
Lee Ji-Won
Abstract
Background: Visceral abdominal fat is a known risk factor for the kidney diseases and cystatin C which is a better marker
for kidney function is increased in obese patients. The aim of this study is to evaluate the correlation between the visceral
adiposity measured by computed tomography (CT) of the abdomen and serum cystatin C level in healthy individuals
with normal kidney function.

Methods: 318 Healthy individuals with glomerular fi ltration rate (GFR) greater than 60 mL/min/1.73 m2 were included in the study. The questionnaire, physical measurements, blood testing, and CT for visceral fat measurement were carried out. The association between visceral fat and serum cystatin C level or kidney function was investigated by using Pearson’s
correlation and multiple regression analysis.

Results: Signifi cant positive correlation was found between visceral fat and cystatin C (r = 0.284, P < 0.001) where as negative correlation was observed between visceral fat and eGFRcys (r = ?0.820, P < 0.001). After adjustment for confounding variants, the multiple regression analysis demonstrated signifi cant positive correlation between the visceral fat area and serum cystatin C level (P = 0.013) and signifi cant negative correlation between visceral fat and eGFRcys.

Conclusion: In healthy individuals with normal kidney function, the visceral fat was independently associated with the cystatin C level, a marker for early detection of renal dysfunction, which indicates the possible relationship between the
visceral fat and renal dysfunction prior to development of the kidney disease.
KEYWORD
Cystatin C, Visceral Fat, Kidney Disease
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