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KMID : 1039620120020020140
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Korean Journal of Family Practice
2012 Volume.2 No. 2 p.140 ~ p.147
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Association of HbA1c with Metabolic Syndrome in Nondiabetic Adults
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Kwon Yu-Jin
Lee Keun-Mi
Jung Seung-Pil
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Abstract
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Background: Hemoglobin A1c (HbA1c) is associated with increasing prevalence of cardiovascular disease and metabolic syndrome in patients with diabetes mellitus. However, the relationship between HbA1c and metabolic syndrome in nondiabetic adults has been unclear. The aim of this study is to estimate the risk of metabolic syndrome and cardiovascular disease and to fi nd out the cut off point of HbA1c for predicting metabolic syndrome, the association of HbA1c with cardiovascular disease risk factors and metabolic syndrome in the normal range of HbA1c levels in nondiabetic adults.
Methods: The subjects included 1,368 adults who visited the health promotion center of Yeungnam University Medical Center from April to June 2008. We investigated body mass index (BMI), waist circumference, systolic and diastolic blood pressure, HbA1c, fasting plasma glucose, lipid profi le, uric acid, and C-reactive protein. We categorized the HbA1c level below 6.0% into the quartile: group 1, HbA1c<5.3%; group 2, 5.3%≤HbA1c<5.5%; group 3, 5.5%≤HbA1c<5.7%; group 4, HbA1c≥5.7%.
Results: There was a significant difference in BMI, waist circumference, fasting plasma glucose, lipid profile, uric acid except blood pressure, and C-reactive protein between groups according to HbA1c levels. The prevalence of metabolic syndrome is signifi cantly increased according to increase of HbA1c (P<0.001). The cut off point of HbA1c which predicts
metabolic syndrome was 5.45%. After adjusted age and sex, odds ratio of metabolic syndrome is progressively increased
compared with lowest HbA1c group: group 2, 2.4 (95% confi dence interval [CI], 0.9-6.2); group 3, 2.5 (95% CI, 1.0-6.3);
group 4, 3.3 (95% CI, 1.3-8.2).
Conclusion: We suggest that HbA1c can be used as a factor to predict metabolic syndrome and cardiovascular risk in nondiabetic adults.
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KEYWORD
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Metabolic Syndrome X, Hemoglobin A1c Protein, Cardiovascular Diseases
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