|
KMID : 1039620120020020148
|
|
Korean Journal of Family Practice
2012 Volume.2 No. 2 p.148 ~ p.154
|
|
|
Relationship between Arterial Stiffness and QTc Interval
|
|
Park Sung-Won
Choi Ji-Ho
Son You-Na
Park Kwang-Shik
Lee Ji-Won
|
|
|
Abstract
|
|
|
Background: Arterial stiffness is an efficient tool for early diagnosis of atherosclerosis and prediction of cardiovascular disease, and it has been known recently that the electrocardiogram QT interval is related to many cardiovascular diseases. In this study, we analyzed the relationship between arterial stiffness and corrected QT (QTc) interval in adults with no cardiovascular diseases who had visited family medicine clinics.
Methods: Questionnaires, physical measurements, blood pressure measurements, and lab tests were carried out in 603 adults (39.28±11.59 years). Brachial-ankle pulse wave velocity was measured, and QTc interval was measured by a standard 12-lead electrocardiogram.
Results: Pearson correlation showed a statistically positive correlation with age (r=0.222, P<0.001), body mass index (r=0.097, P=0.02), waist-hip circumference ratio (r=0.215, P<0.001), fasting plasma glucose (r=0.179, P<0.001), and fasting insulin (r=0.091, P=0.03) from QTc interval. Brachial-ankle pulse wave velocity showed a positive correlation with QTc interval (r=0.196, P<0.001). Multiple regression analysis after adjusting for age, sex, body mass index, systolic blood pressure, total cholesterol, high density lipoprotein, triglyceride, fasting plasma glucose, fasting insulin, and C-reactive protein showed a signifi cant positive relationship with the QTc interval independent from brachial-ankle pulse wave velocity (P<0.01).
Conclusion: There is a significant relationship between arterial stiffness and QTc interval, and QTc interval tends to increase as arterial stiffness increases. Therefore, those in primary care with increased QTc interval should be evaluated for risks of cardiovascular diseases as a primary prevention against cardiovascular diseases.
|
|
|
KEYWORD
|
|
|
Arterial Stiffness, QTc Interval, Echocardiogram
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|