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KMID : 1039620130030020177
Korean Journal of Family Practice
2013 Volume.3 No. 2 p.177 ~ p.183
Relationship between Concentration of Ni, Pb, Cd, Zn in Hair Tissue and Hypertension
Ahn Bang-In

Lee Hyeon-U
Kim Moon-Jong
Park Kyung-Chae
Park Kye-Seon
Lee Yeon-Jung
Seo Eun-Kyung
Kim Joo-Yeon
Kim Seong-Rae
Abstract
Background: Toxic elements such as cadmium, lead, and nickel have been reported to be involved in oxidative damage. On the other hand, zinc defi ciency results in oxidative damage and infl uences the stability of membrane structures and the pathogenesis of hypertension. Thus, the objective of this study was to evaluate the association between hypertension and the toxic elements cadmium (Cd), lead (Pb), and nickel (Ni), and the antioxidant zinc (Zn) by measuring the concentrations of the elements in hair samples.

Methods: The subjects were composed of 231 hypertensive patients (131 men and 100 women) and 612 normotensive controls (295 men and 317 women). A total of 843 people (426 men and 417 women) were included in this study, and we evaluated the association between hypertension and the toxic elements Cd, Pb, Ni, and antioxidant Zn.

Results: The concentrations of Cd and Pb in hair samples were significantly higher and the concentration of Zn was significantly lower in hypertensive patients. However, there was no significant difference in concentration of Ni. In addition, in hypertensive patients, there was a negative correlation between Cd, Pb, and Zn (coeffi cient Zn?Cd=-0.071, P=0.04; coefficient Zn?Pb=-0.105, P=0.002). After adjusting for multiple variables, the odds ratio of hypertension was decreased by Zn level (odds ratio [OR], 0.947) and increased by Cd and Pb level (OR, 1.080, 1.003).

Conclusion: This study showed that deficiency of antioxidant (Zn) and high exposure to toxic metals (Cd and Pb) are
associated with hypertension or the prevalence of hypertension.
KEYWORD
Cadmium, Lead, Nickel, Zinc, Hypertension
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