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KMID : 1039620130030030245
Korean Journal of Family Practice
2013 Volume.3 No. 3 p.245 ~ p.254
Late-Onset Hypogonadism
Kim Kwang-Min

Abstract
The diagnosis of androgen defi ciency should be made only in men with consistent symptoms and unequivocally low serum testosterone levels. Low libido, erectile dysfunction and hot fl ushes, as well as less specifi c symptoms such as fatigue and loss of vigor, irritability and depressed mood, poor concentration, reduced physical performance and sleep disturbance were associated with low testosterone levels. For most symptoms, the average testosterone threshold corresponded to the lower limit of the normal range for young men, i.e., approximately 300 ng/dL (10.4 nmol/L), with a greater likelihood of having symptoms below this threshold than above it. Testosterone therapy for men with symptomatic androgen defi ciency induces and maintains secondary sex characteristics, and improves their sexual function, sense of well-being, muscle mass and strength, and bone mineral density. When testosterone therapy is instituted, we suggest maintaining testosterone levels during treatment in the mid-to-normal range with any of the approved formulations, chosen on the basis of the patient¡¯s preference, and with consideration of pharmacokinetics, treatment burden, and cost. Men receiving testosterone therapy should be monitored using a standardized plan.
KEYWORD
Androgen Defi ciency, Testosterone, Hypogonadism, Anopause
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