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KMID : 1039620130030030338
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Korean Journal of Family Practice
2013 Volume.3 No. 3 p.338 ~ p.344
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The Effect of Primaquine Dosage on the Recurrence of Vivax Malaria
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An Joon-Ho
Byeon Hyeong-Kyu
Kang Han-Sam
Lee Seung-Hwan
Park Sung-Ho
Lim Won-Geol
Shin Joo-Youn
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Abstract
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Background: The recurrence rate of vivax malaria, the only endemic malaria species in the Republic of Korea, has been increasing recently. Thus, we investigated all patients with vivax malaria who visited Gimpo-Woori Hospital located in a high risk area of vivax malaria. In this study, we analyzed the effect of primaquine dosage on the recurrence of vivax malaria.
Methods: We retrospectively reviewed 239 patients with vivax malaria infection diagnosed by Gimpo-Woori Hospital in the northwest of Gyeonggi-do from January 2005 to December 2011. We investigated factors related to the recurrence of vivax malaria such as age, sex, weight, residential area, total dosage of medications, time lag between symptom onset and fi rst medication.
Results: There was no significant difference in the recurrence rates according to sex. However, among male patients, the mean weight of the recurrent patients was signifi cantly higher and the total dosage of primaquine per weight was signifi cantly lower than non-recurrent patients. There was negative correlation between the recurrence of vivax malaria and the total dosage of primaquine per weight among male patients in the multivariate logistic regression analysis after adjusting for other variables such as age, time lag between symptom onset, fi rst medication, and residential area (odds ratio, 0.173; 95% confi dence interval, 0.031 to 0.958).
Conclusion: Insufficient dosage of primaquine affected the recurrence of vivax malaria, in this study. Therefore, the recurrence of vivax malaia could be prevented by appropriate admistration of primaquine according to the patient’s weight, especially in males.
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KEYWORD
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Vivax Malaria, Recurrence, Weight, Primaquine
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