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KMID : 1039620130030040431
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Korean Journal of Family Practice
2013 Volume.3 No. 4 p.431 ~ p.436
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Association between Carotid Intima-Media Thickness, Brachial-Ankle Pulse Wave Velocity and Carcinoembryonic Antigen in Female Non-smokers
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Hong Jeong-Ah
Park Ki-Deok
Lee Duk-Chul
Lee Ji-Won
Kim Sang-Hwan
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Abstract
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Background: Carcinoembryonic antigen (CEA) is a serologic tumor marker also increased in benign conditions such as
cigarette smoking or infl ammatory diseases. Recent studies reported CEA may be associated with carotid atherosclerosis and metabolic syndrome. We have investigated the relationship between the CEA levels and carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (PWV) in healthy female non-smokers.
Methods: A total of 124 healthy female non-smokers were analyzed with a questionnaire, anthropometric measurements, blood tests, IMT, and PWV measurements. The association between CEA, IMT, and PWV was investigated by using trend analysis according to CEA quartiles. The independent relationship between CEA, IMT, and PWV was assessed with multiple regression analysis after adjustment for confounding factors.
Results: IMT and PWV increased with increasing quartiles of serum CEA levels (P for trend <0.05). IMT showed a signifi cant difference between the 1st quartile and 4th quartile of serum CEA levels (P<0.01). PWV showed a signifi cant ifference between the 1st quartile, 2nd quartile with 4th quartile (P<0.01). In addition, serum CEA demonstrated a significant
independent relationship with IMT (β=0.054, P=0.008), but no signifi cant relationship was observed between serum CEA
level and PWV.
Conclusion: In healthy female non-smokers, serum CEA level was independently associated with IMT, which is a marker for atherosclerosis. Our fi ndings indicate that CEA may be a new candidate biomarker for the prediction of risk associated with cardiovascular disease, as well as a tumor marker.
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KEYWORD
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Carcinoembryonic Antigen, Atherosclerosis, Cardiovascular Diseases
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