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KMID : 1039620140040010061
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Korean Journal of Family Practice
2014 Volume.4 No. 1 p.61 ~ p.69
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Use of Nonsteroidal Anti-infl ammatory Drugs and Risk of Fracture: Systematic Review and Meta-Analysis of Observational Studies
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Jo Han-Sang
Cho Jung-Soo
Yoon Hyoung-Ho
Seo Ye-Seong
Eom Chun-Sick
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Abstract
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Background: Previous studies have reported inconsistent fi ndings regarding the relationship between nonsteroidal antiinflammatory drug use and risk of fracture. We investigated this association using a meta-analysis of observational
studies.
Methods: We searched MEDLINE (PubMed), EMBASE, Cochrane Library from inception through February 2012 using common key words. We included case-control, nested case-control and cohort studies. Two evaluators independently reviewed and selected articles. To assess the quality of the studies, the Newcastle-Ottawa Quality Assessment Scale was used.
Results: Of 7,281 articles, meeting our initial inclusion criteria, 4 case-control studies and 3 cohort studies were included in the fi nal analysis. The pooled odds ratio for any fracture was 1.35 (95% confi dence interval, 1.20 to 1.51) with the use of nonsteroidal anti-infl ammatory drugs when compared with non-use.
Conclusion: We found possible evidence linking use of nonsteroidal anti-inflammatory drugs to an increased risk of fracture. Common use of nonsteroidal anti-infl ammatory drugs with the potential risk of fracture is of great importance to public health. Clinicians should consider carefully their decision to prescribe nonsteroidal anti-infl ammatory drugs for
patients already have an elevated risk of fracture.
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KEYWORD
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NSAIDs, Fractures, Bone, Risk assessment, Meta-Analysis
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