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KMID : 1039620140040010070
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Korean Journal of Family Practice
2014 Volume.4 No. 1 p.70 ~ p.76
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Risk Factors for Contrast-Induced Nephropathy after Contrast-Enhanced Computed Tomography in Hospitalized Patients
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Jung Yong-Hyun
Lee Ka-Young
Park Da-Jung
Park Tae-Jin
Lee Hyun-Joo
Lee Chae-Hun
Yun Hyung-Seon
Kim In-Cheon
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Abstract
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Background: We aimed to examine the development, occurrence time, and risk factors for contrast-induced nephropathy (CIN), contrast-induced renal insuffi ciency (CIRI) and related dialysis after contrast-enhanced computed tomography (CECT) was performed.
Methods: We analyzed data from 1,716 patients who were admitted to Busan Paik Hospital and had undergone CECT and at least one serum creatinine (SCr) test within3 days after CECT over a period of 1 year. CIN was defi ned as an increase in SCr by ≥25% or ≥0.5 mg/dL within 3 days after CECT, compared to baseline SCr (SCrbaseline).
Results: In this cohort of patients, 11.2%, 5.9%, and 1.2% developed CIN, CIRI, and dialysis, respectively. Patients with diabetes, liver cirrhosis, high SCrbaseline (>1.5 mg/dL), blood urea nitrogen/creatinine >20, and low albumin (≤3.5 g/dL) had a higher risk for development of CIN. CIRI was more likely to develop in those with hypertension, low hematocrit
(<39% for men 36% for women), high SCrbaseline, and low albumin. Patients who had dialysis were more likely to have low hematocrit and high SCrbaseline. In the patients who had SCr measured within three consecutive days after CECT (n=451), 22.1% developed CIN. Of these patients, 55.8%, 22.1%, and 22.1%, respectively developed CIN on the 1st, 2nd, and 3rd day after CECT.
Conclusion: CIN frequently occurred after CECT. Hypertension, diabetes, liver cirrhosis, dehydration, low hematocrit, high SCrbaseline, and low albumin were responsible for CIN development.
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KEYWORD
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Contrast Media, Renal Disease, Tomography, X-Ray Computed
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