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KMID : 1039620140040010077
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Korean Journal of Family Practice
2014 Volume.4 No. 1 p.77 ~ p.81
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Variations in Adequate Levothyroxine Replacement after Total Thyroidectomy
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Park Sun-Hee
Chung Hee-Seok
Son Hyo-Rim
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Abstract
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Background: To determine the factors that affect levothyroxine (LT4) requirements following total thyroidectomy.
Methods: This study evaluated 42 patients who had undergone total thyroidectomy. At steady state, adjustments were
made in each patient’s LT4 dosage until the target thyroid stimulating hormone concentration was reached.
Results: Fourty-two patients were included (22 women and 20 men). On multivariate analysis we found that thyroxine
requirements were correlated with body mass index (P=0.04). Thyroxine requirements tended to increase with increments
of lean body mass (LBM) and body surface area (BSA), but the increase was not statistically significant (respectively,
P=0.783, P=0.51). Analysis indicated patient age, sex, and body weight did not independently infl uence LT4 dosage.
Conclusion: The initial replacement dose of LT4 following total thyroidectomy for thyroid cancer increased with increments
of body mass index. Replacing LT4 based on BMI is the ideal method, and could even be improved if the BSA and LBM are taken into consideration.
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KEYWORD
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Thyroid Cancer, Thyroxine, Thyroidectomy
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