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KMID : 1039620140040020131
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Korean Journal of Family Practice
2014 Volume.4 No. 2 p.131 ~ p.136
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The Relationship between Tumor Markers and Obesity
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Kim Go-Eun
Jung Sung-Kweon
Chung Chi-Young
Kim Ji-Eun
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Abstract
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Background: Tumor markers are used to help in the early detection of cancer, to measure effectiveness after treatment, and to check for recurrence of cancer. Tumor markers are infl uenced by many factors. In this study, we analyzed the relationship between the representative tumor markers (alpha-fetoprotein [AFP], carcinoembryonic antigen [CEA], cancer antigen 125, cancer antigen 19-9 [CA19-9], prostatic specifi c antigen [PSA]) and obesity status using body mass index (BMI).
Methods: We calculated BMI based on height and weight of a total of 320 males and females who visited the health promotion center. The candidates were divided into a normal weight group, an overweight group, and an obese group according to their BMI. We analyzed the correlation between BMI and tumor markers.
Results: In the male obesity group, the correlation coeffi cients between BMI and AFP, CEA, CA19-9 were -0.214, -0.094, -0.213 which were all statistically insignifi cant (P=0.097, P=0.469, P=0.1). However, the correlation coeffi cient between BMI and PSA was statistically significant (-0.288, P=0.024). In men, the correlation coefficient between BMI and PSA was ?0.159 and it was statistically signifi cant (P=0.044). BMI was not signifi cantly correlated with any tumor markers in women.
Conclusion: Among tumor markers, only PSA showed signifi cantly negative correlation with BMI. It may be considered a reference point for PSA normal range according to obesity.
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KEYWORD
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Tumor Marker, Body Mass Index, Obesity, alpha-Fetoproteins, Carcinoembryonic Antigen, CA-125 Antigen, Cancer Antigen 19-9, Prostatic Specifi c Antigen
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