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KMID : 1039620140040030227
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Korean Journal of Family Practice
2014 Volume.4 No. 3 p.227 ~ p.231
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Correlation between Serum Homocysteine Level and Framingham Risk Score
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Kim Hee-Jun
Min Hong-Gi
Kim Yu-Lee
Lee Sang-Keun
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Abstract
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Background: Serum homocysteine level is an independent risk factor for the development of coronary heart disease. Framingham risk score (FRS) is also used as a conventional clinical risk score to evaluate cardiovascular disease. We studied the association between serum homocysteine levels and Framingham risk score.
Methods: This study was performed with 675 adults aged from 23 to 78 years old. Medical and smoking history was assessed by a questionnaire in a health examination center. Serum concentrations of homocysteine were measured with competitive immunoassay using a direct chemiluminescent technique.
Results: Serum concentration of homocysteine was correlated with FRS (total participants: r=0.292, P<0.001; men: r=0.108, P=0.024; women: r=0.243, P<0.001). The homocysteine concentrations between the three risk groups (<10%, 10?20%, >20%) were different from each other.
Conclusion: Serum concentration of homocysteine is correlated with FRS, but the correlation coefficient was not high.
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KEYWORD
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Homocysteine, Cardiovascular Diseases, Risk Assessm
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